Recurrent herpes simplex type 2 virus mollaret meningitis jabfm. For me it has taken the battle out of my head and instead to somewhere i. We found the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 hsv2 was 2. We present a case of a 27yearold woman with mollarets meningitis related to viral infection with herpes simplex virus type 2 confirmed by cerebrospinal fluid. It is characterized by repeated episodes of meningitis. Herpes simplex virus type 2 has been the most commonly identified causative agent of mollarets meningitis. Herpes simplex virus type 2associated recurrent aseptic mollaret s meningitis in genitourinary medicine clinic.
Mollarets meningitis is a rare disease characterized by recurrent, selflimited episodes of aseptic meningitis. Is mollarets meningitis caused by herpes simplex virus type 2. The peripheral white blood cell count alone is not help. Mollarets meningitis is a rare form of benign, recurrent aseptic. In recent years there has been increasing evidence to implicate the herpes simplex virus 2 hsv2 in many cases. The disease is characterised by recurrent at least three episodes, benign no longterm sequelae and brief 25 day episodes of aseptic lymphocytic meningitis, alternating with symptomfree interval, mostly caused by hsv2 infection. Mollarets meningitis is an unusual but perhaps underappreciated syndrome of benign, recurrent, aseptic meningitis. Herpes simplex virus type 2associated recurrent aseptic mollarets. Cases of idiopathic recurrent benign aseptic meningitis were first described by.
Apr 19, 2014 the community has truly come to feel like a family, somewhere i can be open, honest and myself. Nov 01, 2006 recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. Objective to evaluate cognitive outcome in unselected patients with previously diagnosed viral meningitis. Mollaret s meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Mollarets meningitis is a rare condition with a characteristic clinical and cerebrospinal fluid picture. Mollarets meningitis should be suspected in all cases of recurrent lymphocytic meningitis.
This may not be the complete list of references from this article. Should mollarets meningitis always be treated with antihsv. Mollarets meningitis the lancet infectious diseases. Mollarets meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. Sep 02, 2016 mollaret meningitis is thought to be rare. Mollaret meningitis genetic and rare diseases information center. A patient who initially presented with clinical and laboratory signs of bacterial meningitis developed four more similar episodes within a 6month period. Definition of mollaret syndrome in the medical dictionary by the free dictionary. Mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Mollaret syndrome definition of mollaret syndrome by. In the remainder, infective, neoplastic and socalled aseptic disorders may be identified.
With the suspicion of mollaret s meningitis a new lumbar puncture was performed and csf was sent for pathologic examination showing the presence of large mononuclear cells. Analysis of candidatehost immunogenetic determinants in. Mollaret meningitis, recurrent aseptic meningitis, fever. Mollaret s meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever. Mollaret meningitis synonyms, mollaret meningitis antonyms. Mollaret s meningitis is caused by herpes simplex virus. When can the management of meningitis become difficult. The disease is characterized by repeated episodes of. Mollaret meningitis with a high level of cytokines in the. Mild cognitive impairment after viral meningitis in adults. The disease is characterized by repeated episodes of fever and signs of meningeal inflammation that usually subside within 25 days after onset. Mollaret s meningitis is felt to be rareso if you ve got a client with confirmed mollaret s. Ideal sources for wikipedias health content are defined in the guideline wikipedia. Broadly speaking, there are three main potential areas of concern.
The community has truly come to feel like a family, somewhere i can be open, honest and myself. Mollarets recurrent aseptic meningitis and cerebral. Looking for online definition of mollaret syndrome in the medical dictionary. Chronic meningitis is defined as the persistence of clinical symptoms and signs of meningitis, with or without abnormal cerebrospinal fluid, for more than four weeks. Kinohshita t, matsushima a, satoh s, et al 2014 a case of colchicineresponsive mollarets meningitis with mefv gene mutation. Mollaret meningitis journal of the neurological sciences. Because of its rarity, it is difficult to estimate the exact number of individuals affected by this condition.
Mollaret meningitis is a rare form of meningitis that is recurrent. Difficult and recurrent meningitis journal of neurology. Mollaret meningitis was first described by mollaret in 1944 as a form of aseptic meningitis. Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and meningeal irritation with no obvious etiology. We report a case of mollaret meningitis in a sevenyearold girl who presented with four aseptic meningitis episodes in one year. Cranial computed tomography performed during the acute phase of the initial episode was normal, but, after the. Chronic and recurrent meningitis practical neurology. Get a printable copy pdf file of the complete article 869k. Mollaret s meningitis and differential diagnosis of recurrent meningitis. Benign recurrent aseptic meningitis mollarets meningitis. Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and. In many ways it resembles recurrent hereditary polyserositis familial mediterranean fever in its natural history, pattern of attacks, and response to colchicine. The disease is characterised by recurrent at least three episodes, benign no longterm sequelae. This syndrome is associated with transient neurological symptoms in onehalf of afflicted patients.
Recurrent benign lymphocytic meningitis clinical infectious. Mollaret meningitis article about mollaret meningitis by. Mollaret s meningitis is a rare disease characterized by recurrent, selflimited episodes of aseptic meningitis. Herpes simplex type 2 virus is the causative agent in virtually all cases. Mollarets meningitis an overview sciencedirect topics. Patients typically experience episodes of fever and meningism of abrupt onset lasting 34 days. Benign recurrent aseptic meningitis is a rare disorder described by mollaret in 1944.
Herpes simplex virus type 2associated recurrent aseptic mollarets meningitis in genitourinary medicine clinic. Mollarets meningitisrecurrent aseptic meningitishsv2 virus. Mollarets meningitis and herpes simplex virus type 1 nejm. Mollaret s meningitis is an unusual but perhaps underappreciated syndrome of benign, recurrent, aseptic meningitis. Jan 25, 2019 mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Table 1 causes of an aseptic meningitis cerebrospinal fluid picture in this article, the major causes of meningitis are considered in turn, highlighting the difficulties which may arise under these three headings. Mollarets meningitis benign recurrent aseptic meningitis. Find mollarets meningitis information, treatments for mollarets meningitis and mollarets meningitis symptoms. Jan 01, 2000 mollarets meningitis is an unusual but perhaps underappreciated syndrome of benign, recurrent, aseptic meningitis. The 35yearold praised simon read and matthew laws from the east of england ambulance service nhs trust eeast for their care after her condition rapidly deteriorated. Mollarets meningitis is caused by herpes simplex virus. It is characterized by repeated episodes of meningitis, typically lasting two to five days, occurring weeks to years apart. In the original description of three patients with recurrent episodes of meningitis over a 15year period, the csf was notable for a leukocytosis and an unusual cell type originally thought to be of endothelial origin. It has been suggested that if the strict criteria above are followed, these cases should be excluded, and the term mollaret s meningitis reserved for true idiopathic cases.
Diagnosis, initial management, and prevention of meningitis. Mollarets meningitis international journal of infectious diseases. Pdf on oct 1, 2014, zaw min and others published mollarets meningitis find, read and cite all the research you need on researchgate. Check the full list of possible causes and conditions now.
Early diagnosis may prevent prolonged hospital admissions. Possible causes include generalized herpes simplex. Until recently, this syndrome had been considered a disease of unknown etiology. Mollaret s meningitis has been characterized by unique abnormalities found on serial csf examinations. Mollarets meningitis is a rare form of idiopathic recurrent aseptic meningitis that has a sudden onset, short duration, and spontaneous remission. Synonyms for mollaret meningitis in free thesaurus. Mollaret meningitis genetic and rare diseases information. The disease is most often caused by herpes simplex virus type 2 hsv2 and less frequently by other viruses, autoimmune disorders, or medication.
For me it has taken the battle out of my head and instead to somewhere i can get advice or simply tell about my daily struggles and triumphs. The syndrome of benign recurrent aseptic meningitis of unknown cause is called mollaret s meningitis. When initially described, this form of aseptic meningitis had no identifiable infecting. A tentative diagnosis of mollaret s meningitis was established after the third episode. In many ways it resembles recurrent hereditary polyserositis. Since mollaret s meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. Mollarets meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever. The features of these activated monocytes were compatible with those of mollarets cells, and csf herpes simplex virus type 2 hsv2 pcr assay. Mollaret meningitis definition of mollaret meningitis by. Mollarets meningitis is an unusual and underappreciated syndrome of benign, recurrent aseptic meningitis. Important infective causes include partially treated bacterial pyogenic. Common signs and symptoms during an episode may include severe headache, fever, nausea, vomiting, sensitivity to light photophobia, and stiff neck. Mollarets meningitis and herpes simplex virus type 2.
Amanda has been living with mollarets meningitis a rare recurring viral form of the disease for more than six years. A case of recurrent benign lymphocytic mollarets meningitis and. A rare form of aseptic meningitis characterized by a recurrent pattern with symptomfree intervals between episodes. Mollarets meningitis fulltext european neurology 2008, vol. Pdf herpes simplex virus type 2 mollarets meningitis. Herpes simplex virus type 2associated recurrent aseptic. Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Pdf mollarets meningitis is a rare disease characterized by recurrent and self limited episodes of lymphocytic. As stated by many authors, mollarets meningitis should only be referred to recurrent aseptic meningitis with unknown aetiology after throughout studies including molecular tehcniques. Mollarets meningitis and herpes simplex virus type 2 infections. Recurrent lymphocytic meningitis positive for herpes simplex.
Recurrent lymphocytic meningitis rlm is a rare disease, characterized by attacks of sudden onset aseptic meningitis followed by complete recovery and unpredictable recurrences. Methods twentyone unselected patients were examined. Abstractmollarets meningitis is a rare disease characterized by recurrent and selflimited. Recurrent lymphocytic meningitis positive for herpes. A rare case of mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during a threeyear period is reported. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. However, recent research and studies have suggested that it may be more common than initially thought. Fulltext pdf recurrent aseptic meningitis with reversible cerebral vasoconstriction. Looking for online definition of mollaret meningitis in the medical dictionary. Recurrent aseptic meningitis secondary to intracranial epidermoid cyst and mollarets meningitis. Should mollarets meningitis always be treated with anti. In as many as one third of cases, no cause is found.